SCIENCE AND TECH
Colorectal cancer (CRC) outcomes vary, even among patients with node-negative disease. While the absence of lymph node involvement often suggests a better prognosis and less aggressive treatment, not all cases follow this pattern.
Perineural invasion (PNI), cancer spreading to or around nerves, can signal a higher risk despite negative nodes. Its presence prompts new discussions about post-surgical chemotherapy. As research deepens, PNI is becoming a key factor in shaping evolving treatment strategies for node-negative CRC patients, highlighting that even within lower-risk groups, personalized care is crucial.
Understanding Node-Negative Colorectal Cancer and Perineural Invasion
Node-negative colorectal cancer (CRC), typically stage I or II, has not spread to regional lymph nodes and usually has a favorable prognosis with surgery alone. However, staging doesn’t reveal every risk.
Perineural invasion (PNI), cancer cells growing in or around nearby nerves, offers a hidden pathway for cancer to spread, even when nodes are clear. Detected microscopically, PNI increases the chance of local or distant recurrence.
Though still under study, PNI appears to help cancer cells evade the immune system and survive in the tissue environment, suggesting a more aggressive disease that may require closer monitoring or additional treatment.
Methods for Identifying Perineural Invasion in CRC Specimens
Diagnosing PNI requires careful pathological sampling and review. After surgical removal of the tumor, pathologists slice the specimen and examine the tissue under a microscope. They look for cancer cells encasing or tracking along nerves in the colorectal wall or surrounding fat.
Typical diagnostic criteria include the presence of tumor cells within any of the three layers covering a nerve or in direct contact with neural structures. This process is not always straightforward. The nerves involved are often tiny, and…
CURRENT EDITION
WEATHER
TODAY
RH
WASHINGTON BUREAU
Secretary of State Marco Rubio Discusses Progress in Ukraine-Russia Talks
In a recent interview with Fox Business Network’s Larry Kudlow, Secretary of State Marco Rubio
Trilateral Cooperation Boosts Security Preparations for 2026 FIFA World Cup
In a historic move towards ensuring the safety and success of the 2026 FIFA World
Study Reveals Alarming Gaps in HIV Prevention for Infants, Highlighting Racial Disparities in Treatment
A recent study has uncovered alarming statistics regarding HIV prevention efforts for infants, particularly concerning those exposed to HIV during pregnancy and birth. Newborns diagnosed with HIV are supposed to receive immediate antiretroviral medication after delivery to significantly reduce the risk of transmission from mother to child. However, the…
New York State Launches Empire State Cellular Therapy Consortium to Accelerate Cancer Treatments
To expand on early progress in the emerging field of cell and gene therapy, five research centers across New York State are collaborating to develop new cell therapies for cancer and other diseases. Roswell Park Comprehensive Cancer Center in Buffalo, the University of Rochester Wilmot Cancer Institute in Rochester…
U.S. and Israel Forge Partnership to Enhance Energy Security Through AI
In a significant step towards bolstering energy security and innovation, U.S. Secretary of Energy Chris Wright and Secretary of the Interior Doug Burgum, who serve as vice chair and chair of the National Energy Dominance Council (NEDC), signed a Memorandum of Understanding (MOU) with Israeli Prime Minister Benjamin Netanyahu…
How Companies Like W.A. Rasic Construction Build Underground Infrastructure That Shapes the Cities of Tomorrow
As cities continue to grow taller and smarter, the systems that make them work are being built further underground. We often marvel at new high-rises or tech-powered transit hubs, but it’s the hidden infrastructure that companies like W.A. Rasic Construction establish—the power lines, data conduits, and utility pipelines—that…
Brooklyn Friends School Redefines Excellence in NYC Education
Nestled in Downtown Brooklyn amid the metropolitan rush, Brooklyn Friends School (BFS) stands as both a historical landmark and an educational innovator, serving students from ages two through high school. Founded in 1867 by the Religious Society of Friends, the school ranks among New York City’s oldest continuously…
Administering the hormone leptin appears to resolve a dangerous complication of insulin insufficiency, new research shows
In a groundbreaking analysis published in The Journal of Clinical Investigation, researchers have revealed promising findings about the hormone leptin and its potential to treat diabetic ketoacidosis (DKA), a serious complication associated with type 1 diabetes. This research, spearheaded by Dr. Michael Schwartz from the University of Washington School of Medicine, highlights how leptin can normalize blood sugar levels even in the absence of insulin.
DKA occurs when the body cannot produce insulin, causing it to break down fat for energy. This process leads to a dangerous surge of sugar and ketoacids in the bloodstream, typically managed through insulin therapy. However, recent investigations show that the brain significantly influences DKA, particularly when insulin levels are low.
Schwartz explains, “When the pancreas cannot produce insulin, the brain receives signals indicating a lack of fuel, despite the body having reserves. One key factor in this communication is the blood level of leptin, which is produced by fat cells.”
Leptin is known for its role in appetite control and energy balance. When levels are insufficient, it triggers the brain to mobilize energy stores, including glucose and ketones. Schwartz’s research team first observed the impact of leptin in 2011, administering it…
Achievement expands what’s possible in stockpile stewardship experiments
In a remarkable advancement in fusion research, a team led by the Los Alamos National Laboratory (LANL), in collaboration with the Lawrence Livermore National Laboratory (LLNL), has successfully achieved ignition using the National Ignition Facility. This milestone was reached during a groundbreaking experiment conducted on June 22, which yielded an impressive 2.4 ± 0.09 megajoules of energy. The team created a self-sustaining feedback loop known as a “burning plasma,” representing a significant leap in the quest for controlled fusion energy.
“This shows how well our designs can create fusion ignition conditions to address key stockpile stewardship questions,” stated Joseph Smidt, a LANL physicist and co-director of the inertial confinement fusion program. This experiment marks the first deployment of LANL’s Thinned Hohlraum Optimization for Radflow (THOR) window diagnostic system. THOR, using a modified version of LLNL’s ignition platform, produces extreme X-ray output that will aid scientists in testing materials under intense radiation.
Ryan Lester, Lab physicist and THOR campaign lead, emphasized the teamwork that made this achievement possible. “This fantastic result is only possible because of the team of people working together. We pulled this off in less than a year because of everyone’s commitment. We moved fast and we moved together,…
How Automated Turning Mattresses Actually Work: The Technology Behind Pressure Injury Prevention
When Mark’s father was admitted to the hospital after a stroke, the family didn’t think much about the mattress he was lying on. It looked ordinary enough—until they noticed it was quietly moving him from side to side every few minutes, adjusting pressure points, and somehow keeping him comfortable…
Breakthrough Solar Technology: NUS Scientists Achieve World-Record Efficiency in Perovskite-Organic Tandem Solar Cells
Scientists at the National University of Singapore (NUS) have demonstrated a perovskite–organic tandem solar cell with a certified world-record power conversion efficiency of 26.4 per cent over a 1 cm2 active area — making it the highest-performing device of its kind to date. This milestone is driven by a newly designed…
Targeting Fusion Protein’s Role in Childhood Leukemia Produces Striking Results
Scientists at St. Jude Children’s Research Hospital and Dana-Farber Cancer Institute today report the identification of a novel combination therapy approach to treat pediatric acute myeloid leukemia (AML). Standard treatment is often ineffective against AML, a cancer that commonly relapses with poor prognosis, particularly when the disease is fueled by…
What We’re Seeing in Schools as Pandemic-Era Funding Ends
As pandemic-era federal aid for K–12 schools phases out, districts are entering a critical juncture that demands sharper prioritization, quicker decision-making, and a renewed focus on student impact.
Over $1.1 billion in temporary education funding has ended nationwide, funding that helped support tutoring, student wellness, and learning recovery initiatives during…
Big Outsource Offers Critical Data Entry Outsourcing Solutions for SMEs Seeking Efficiency
Small business owners often find themselves buried under a mountain of data: orders to process, inventory spreadsheets to update, and financial records to keep in check. Data entry outsourcing solutions have emerged as the game-changer these businesses desperately need. Rather than investing in a shiny new product or…
Sensory-seeking behavior in children can be puzzling, even overwhelming, for parents. This behavior often involves actions that seem excessive or concerning, such as constant movement, touching objects, or a need for loud noises. The child may struggle to keep their hands to themselves, and frequent prompts and reminders may not override their impulse to seek the desired stimulation. Sensory seeking behavior can also present with a child being heavy-handed in their actions, while hypersensitive to touch themselves, which can be confusing and frustrating to parents and caregivers. While it can be disruptive, these actions are a way for children to meet critical sensory needs that can provide a sense of calm and comfort, while contributing to overall brain development.
Understanding sensory-seeking behavior is essential for parents to support their child’s well-being and foster healthy development. By recognizing and supporting these actions in constructive ways, parents can help their children thrive emotionally and socially.
Understanding Sensory-Seeking Actions
While often described as sensory-seeking behaviors, using the word behavior implies that a child has a choice in their actions, versus understanding that a physiological need may drive their actions.
To better support a sensory-seeking child, it helps to first understand what sensory-seeking actions really are and why some kids exhibit them. Seeking increased sensory stimulation stems from the way a child processes sensory input, which can differ significantly from what most people might consider typical. The brain constantly takes in and processes vast amounts of sensory information – nearly instantaneously. Processing this information requires fast and efficient connections in the…
MORE ARTICLES
Green Biotech Hellas: Pioneering Innovative Solutions in Biotechnology, Celebrating Award-Winning Achievements
Quantum Magnets Reveal Exotic Spin Interactions and Open New Frontiers in Quantum Technology
Why Many Seniors Choose Life Alert for Emergency Protection
As the U.S. population ages, more seniors are looking for reliable ways to remain independent while having access to emergency assistance. According to the U.S. Census Bureau, the number of Americans aged 65 and older is expected to reach 82 million by 2050, nearly doubling from 2018. The demand…
Portable HIV Monitoring Device Shows Promise for Remote Settings
Accurate monitoring of CD4+ T cell counts is vital for evaluating immune health and guiding treatment in people living with Human Immunodeficiency Virus (HIV). Yet conventional tools like flow cytometry, while highly effective, are expensive, complex, and ill-suited for widespread use in remote or resource-limited areas. Many portable alternatives remain…
Sonic Booms From Falcon 9 Rocket Launches Prompt Research Initiative
Residents of Ventura County are encountering an increasing phenomenon linked to the frequent launches of SpaceX’s Falcon 9 rocket from the Vandenberg Space Force Base: sonic booms. Even though the launch site is located 60-100 miles away, the sound waves produced by these rocket launches can resonate through the…
Glyfada, Greece – Since its inception in 2008, Green Biotech Hellas has distinguished itself as a trailblazer in biotechnology services, consistently delivering innovative solutions and advancing the field of biology research. Located in the picturesque coastal town of Glyfada, the company has achieved remarkable success in providing a comprehensive range of industrial and environmental biotechnology services to businesses and organizations worldwide.
Green Biotech Hellas’s commitment to excellence is underscored by its impressive collection of innovation awards. The company has been recognized for its contributions to green biotechnology, receiving accolades in the EU in 2012, 2016, 2017, and most recently in 2023. Its accomplishments extend to the United States, where it was honored with awards in 2018, 2020, and 2023, highlighting the company’s impactful role in shaping the biotechnology landscape on both continents.
A Focus on Innovative Research Services
At the core of Green Biotech Hellas’s offerings are its research services in two significant domains: industrial biotechnology and environmental biotechnology. The focus on industrial biotechnology has enabled the company to develop cutting-edge services that range from the detection to the quantification of a wide array of natural and synthetic compounds and biomolecules. These tailored solutions cater to various industries, enabling businesses to…
EDITOR'S
CHOICE
Quantum Magnets Reveal Exotic Spin Interactions and Open New Frontiers in Quantum Technology
Mysterious Underground Structures Beneath the Pyramids of Giza: Sensational Discovery or Another Hoax?
A new wave of interest in Egypt’s ancient civilization surged in the spring of 2025, following claims by a group of Italian researchers. They alleged that, using radar technology, they had discovered a vast underground complex as deep as 1,200 meters beneath the pyramids of Giza.
News outlets ran with…
Researchers Find CRISPR Is Capable of Even More Than We Thought
Every living creature on Earth needs to protect itself from things that would do it harm. Bacteria are no different. And despite their relative simplicity, they deploy remarkably savvy defensive strategies against viral invaders. The most well-known is CRISPR-Cas9, adapted for human use as the first FDA-approved genetic editing…
Building Tomorrow’s Networks Today: The Strategic Case for Structured Cabling in London’s Enterprises
In boardrooms across the capital, digital transformation tops every agenda, yet few executives realise that its success hinges on the first few metres of physical infrastructure inside their premises. The move from on-prem servers to multi-cloud, from legacy telephony to unified communications, from static offices to smart, sensor-rich workplaces—all…