Maxx Quinten 18, Jul 5 mins
5 mins
The Ritz Herald
Iwao Ojima and Martin Kaczocha (foreground). © John Griffin, Stony Brook University
The “FABP” inhibitor is part of a series of compounds that uses the body’s natural marijuana-like substances to curb pain and inflammation

Six years ago Stony Brook University through the Research Foundation for the State University of New York licensed a promising technology to Artelo Biosciences that identified Fatty Acid Binding Proteins (FABPs) as drug targets of the body’s endocannabinoid system for a potentially promising way to treat pain, inflammation and cancer. Now the first one of these compounds has been cleared by the Food and Drug Administration (FDA) for human clinical trials.

Artelo announced this week that the FDA’s initial approval of one of the FABP5 (5 indicates a specific protein) selective compounds called ART26.12 enables the company to initiate its first human phase 1 single ascending dose study of the drug. The company states that ART26.12 will address a critical need for cancer patients, treating chemotherapy-induced peripheral neuropathy. Phase 1 clinical trials are expected to be launched internationally during the first half of 2025.

ART26.12 is the lead compound in the series of FABP5 inhibitors under development. In 2018, Artelo received an exclusive license to the intellectual property of all FABP inhibitors for the modulation of the endocannabinoid system.

The work on FABPs originated with Iwao Ojima, PhD, SUNY Distinguished Professor in the Department of Chemistry at Stony Brook University, Martin Kaczocha, PhD, Associate Professor in the Department of Anesthesiology in the Renaissance School of Medicine at Stony Brook University, and Dale Deutsch, PhD, Professor Emeritus in the Department of Biochemistry and Cell…






Replacing Registered Nurses in High Stakes Hospital Care is Dangerous to Patients
The Ritz Herald

A new study published in Medical Care on Monday showed that substituting registered nurses (RN) with lower-wage staff (e.g. licensed practical nurses, unlicensed assistive personnel) in hospital care is linked with more deaths, readmissions, longer hospital stays, poorer patient satisfaction, and higher costs of care.

The study, by the Center for Health Outcomes…

AI’s Need for Speed: High-Performance Cable Assemblies in the Fast Lane of the Data Race
The Ritz Herald

Artificial Intelligence (AI) and machine learning (ML) are no longer science fiction concepts. They’re powering our daily lives, from personalized recommendations on streaming services to cutting-edge medical diagnostics. Behind the scenes, these technologies are fueled by massive amounts of data that needs to be processed at lightning-fast speeds. And…

New Study Reveals Major Findings on Mutagenic Exposures in Kidney Cancer Genomes
The Ritz Herald

In May, a 7-year study on mutagenic exposures in kidney cancer genomes was published in the journal ‘Nature‘. The study was conducted by an international scientific team and included authors such as Prof. Sonata Jarmalaitė and Dr. Rasa Sabaliauskaitė from the Life Sciences Center of Vilnius University and…

AI: The Game-Changer in Cybersecurity
The Ritz Herald

The rapid advancement of Artificial Intelligence (AI) is revolutionizing various industries, and cybersecurity is no exception. As cyber threats become more sophisticated and complex, traditional security measures are proving insufficient in protecting organizations from potential attacks. AI, however, offers a new paradigm for cybersecurity, promising to transform the way…

Revscale AI’s Web Visitor Tracking Pixel: Turning Anonymous Visitors Into Leads
The Ritz Herald

In the fast-paced, constantly evolving world of digital marketing, many businesses deepen their focus on finding quality leads. However, we find that many are ignoring the ones that are right in front of them – their unknown website visitors. Finding ways to turn anonymous web traffic into solid leads…

3 mins
© AP
The Ritz Herald
Gains in resources flow to more senior than junior women biomedical scientists; ‘gender tenure gap’ factors significantly

Women increasingly populate the ranks of doctoral degree holders in U.S. life-science fields — from 32-38 percent in the mid-1980s to about 55 percent in 2020. But the trend is partly problematic.

Among biomedical scientists, senior women have benefited disproportionately to their junior counterparts in “both funding amount and likelihood,” writes Associate Professor of Management and Organization Waverly Ding at the University of Maryland’s Robert H. Smith School of Business, with her co-authors, in research published at Nature Biotechnology. An underlying factor, she adds, is a structural set of tenure-inhibiting factors.

Ding collaborated with Smith doctoral candidate Beril Yalcinkaya, Chris Liu (University of Oregon’s Lundquist College of Business) and Andy S. Back (University of Hong Kong Business School).

They examined National Institutes of Health (NIH) distribution of 2.3 million grants to biomedical researchers between 1985 and 2017. They also referred to National Science Foundation data on academic scientist tenure trends.

In addition to the research funding gap, their findings illustrate a persisting gender disparity: “Women haven’t entered the tenured ranks in biomedical sciences at a rate commensurate to that of their entrance into the field.” For the past three decades, that probability has been about 20 percent for women and nearly 40 percent…

4 mins
© United
The Ritz Herald
As part of industry-leading efforts to communicate to customers in real-time, airline uses AI tools to send travelers information about their trip, especially if things don't go as planned

United now texts customers links to local, live radar maps during weather delays, as part of its industry-leading effort to give travelers as much real-time information as possible about their trip, especially if things don’t go as planned. For the past few years, the airline has used dedicated teams to write and send text messages to customers that give near-instantaneous details about a given flight – everything from gate changes and boarding times to more specifics regarding aircraft swaps, crew rescheduling and weather events – and the teams now use generative artificial intelligence (gen AI) tools to assist in giving more travelers real-time updates during flight delays.

United’s latest innovation – real-time radar maps – can help customers understand how inclement weather in one part of the country can impact a flight elsewhere. United is the first and only U.S. airline currently providing its customers these kinds of specific messages, and the airline is sending them with assistance from gen AI tools.

“With more people traveling this summer than ever, we wanted to give our customers an easier way to stay connected to real-time information about their flight and texting was the simplest solution,” said Jason Birnbaum, United‘s Chief Information…

Penn Medicine Brings Free 3D Mammograms and Health Screenings Back to West Philly
The Ritz Herald

Penn Medicine will once again join with community partners and Siemens Healthineers to host a free mammogram clinic and community health fair in June, giving the West Philadelphia and Upper Darby communities convenient access to health screenings right in their neighborhoods. The annual events are part of Penn Medicine’s…

Study Shows Breakthrough Infections Boost Immune Response Against SARS-CoV-2 Variants
The Ritz Herald

New research from scientists at La Jolla Institute for Immunology (LJI) suggests people who received COVID-19 vaccines and then experienced “breakthrough” infections are especially well armed against future SARS-CoV-2 infections.

By analyzing blood samples from study volunteers, the LJI researchers discovered that people who experienced symptomatic breakthrough infections develop T…

Honorable Jon Rychalski, VA Chief Financial Officer, Selected as New VP for Financial Operations at Uniformed Services University
The Ritz Herald

The Honorable Jon Rychalski, Assistant Secretary for Management and Chief Financial Officer in the Department of Veterans Affairs, has been named as the new Vice President for Financial Operations at the Uniformed Services University of the Health Sciences (USU) in Bethesda, Md.

As Vice President for Financial Operations, Rychalski will…

IBM and Salesforce Expand Partnership to Advance Open, Trusted AI and Data Ecosystems
The Ritz Herald

IBM (NYSE: IBM) and Salesforce (NYSE: CRM) announced an expanded strategic partnership which will bring together IBM watsonx AI and Data Platform capabilities with the Salesforce Einstein 1 Platform for greater customer choice and flexibility in AI and data deployment. This will empower teams to make data-driven decisions…

Tumor Mutations May Not Predict Response to Immunotherapy
The Ritz Herald

The number of mutations in the DNA of cancerous tumors may not be an indicator of how well patients will respond to immune checkpoint inhibitors (ICIs), a commonly prescribed type of immunotherapy, a team led by UT Southwestern Medical Center researchers reported in a retrospective study. The findings, published in 

5 mins
The Ritz Herald
The US Food and Drug Administration headquarters in White Oak, Maryland. © Sarah Silbireg / Getty Images
Diversity Action Plans to improve enrollment of participants from underrepresented populations in clinical studies
By / Newsroom Staff

U.S. Food and Drug Administration issued a draft guidance, “Diversity Action Plans to Improve Enrollment of Participants from Underrepresented Populations in Clinical Studies,” to assist medical product sponsors in submitting Diversity Action Plans to support certain clinical studies. Diversity Action Plans are intended to increase clinical study enrollment of participants of historically underrepresented populations to help improve the data the agency receives about the patients who may potentially use the medical product.

Enhancing diversity within clinical studies facilitates broader applicability of results across a broad spectrum of patient populations and enhances understanding of the disease or medical product under study, thus providing valuable insights to inform the safe and effective use of the medical product among patients.

“Participants in clinical trials should be representative of the patients who will use the medical products,” said FDA Commissioner Robert M. Califf, M.D. “The agency’s draft guidance is an important step—and one of many ongoing efforts—to address the participation of underrepresented populations in clinical trials to help improve the data we have about patients who will use the medical products if approved.”

This draft guidance describes the format and content of Diversity Action Plans, the medical products and clinical studies for which a Diversity Action Plan is required, and the timing and process for submitting Diversity Action Plans to the FDA. It also outlines the criteria and processes the agency will use to evaluate a sponsor’s request not to submit a required Diversity Action Plan, also known as a waiver.

Diversity Action Plans must specify the sponsor’s rationale and goals…


Eco-Innovation at the Forefront: Saproterra’s Advancements in Organic Materials
Saproterra, an innovative leader in the biotech industry, is setting
FDA Expands Orphan Drug Designation for SurVaxM, Immunotherapy Developed at Roswell Park
The U.S. Food and Drug Administration (FDA) has expanded orphan
Race-Neutral Spirometry Reference Equations Impact COPD Clinical Trial Eligibility, Study Finds
The Ritz Herald

Equations that don’t use racially and ethnically adjusted spirometry results to help determine eligibility for chronic obstructive pulmonary disease (COPD) clinical trials may lead to higher percentages of Black patients enrolled, according to research published at the ATS 2024 International Conference.

“While other researchers have initiated investigations into the effects of…

Boeing ecoDemonstrator to Test Technologies to Improve Cabin Recyclability, Operational Efficiency
The Ritz Herald

Boeing is testing three dozen technologies on its ecoDemonstrator program focused on strengthening operational efficiency and sustainability in cabin interiors, one of the most challenging parts of recycling an airplane. The company will begin testing this month using a 777-200ER (Extended Range).

The Boeing ecoDemonstrator projects include:

  • Airport…
Higher Rates of Cancer in Minoritized Communities Across Chicago and U.S. Driven by Disparities
The Ritz Herald

Despite the overall death rate from cancer in the U.S. falling by 33% between 1991 and 2020, many segments of the U.S. population experience a disproportionate cancer burden, according to the 2024 American Association for Cancer Research (AACR) Cancer Disparities Progress Report.

Communities in Chicago suffer from multiple health disparities, particularly for cancer….

5 mins
© Saproterra
The Ritz Herald
Revolutionizing organic matter utilization for enhanced composite materials and agricultural practices

Saproterra, an innovative leader in the biotech industry, is setting new benchmarks for environmental sustainability and technological advancements with its latest developments in organic fertilizers and biocomposites. Guided by Alex Shynkarou, a seasoned entrepreneur with a deep background in structural engineering and construction, and supported by experts Alex Petrushin and Rob Guarino, who bring extensive knowledge of both domestic and international marketing, Saproterra is not just advocating for a greener planet—it is creating solutions that are effective, safe, and sustainable.

From Construction Expert to Biotech Innovator: Alex Shynkarou’s Sustainable Vision

Alex Shynkarou, the dynamic leader of Saproterra, uses his vast experience in construction and engineering to drive forward-looking projects. Motivated by the quest for safer materials for his family, Shynkarou has catalyzed major innovations in the application and perception of organic matter in both the construction and agricultural sectors.

“As both an engineer in the construction field and a father, I’ve seen firsthand the severe shortcomings of traditional materials,” stated Alex Shynkarou. “Saproterra marks a significant turn towards sustainable, safe materials that are beneficial for our children and our planet.”

Integrating Diverse Expertise for Environmental Breakthrough

The success of Saproterra stems from its approach to amalgamating diverse industry experiences into a unified, sustainable…



FDA Expands Orphan Drug Designation for SurVaxM, Immunotherapy Developed at Roswell Park

Geiger / RH
The U.S. Food and Drug Administration (FDA) has expanded orphan drug designation for SurVaxM, a brain cancer immunotherapy born in the labs of Roswell Park Comprehensive Cancer Center. The supplemental
Blood Pressure Drugs More Than Double Bone-Fracture Risk in Nursing Home Patients
The Ritz Herald

Records from nearly 30,000 nursing home residents indicate that blood pressure medications more than double the risk of life-threatening bone fractures, according to Rutgers Health research.

The authors of the study, which appears in JAMA Internal Medicine, said the increased risk stems from the medications’ tendency to impair balance, particularly…

1 in 5 U.S. Adults Lost to Suicide Had Recent Jail Experience
The Ritz Herald

A newly published study found that one in five U.S. adults who die by suicide spent at least one night in jail in the year prior to their death. Rapidly and efficiently providing prevention, screening and outreach resources for this group is critical to reducing adult suicides nationwide.

“The 7.1…

IBM and SAP Plan to Expand Collaboration to Help Clients Become Next-Generation Enterprises With Generative AI
The Ritz Herald

IBM (NYSE: IBM) and SAP SE (NYSE: SAP) announced their vision for the next era of their collaboration, which includes new generative AI capabilities and industry-specific cloud solutions that can help clients unlock business value.

“IBM and SAP’s shared approach to generative AI, built on an open ecosystem, trust…